Intermittent IV Infusions
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- Module
20- Intermittent IV infusions - Introduction to pharmacokinetics
- IV administration
- Oral administration
- Steady state concept
- Drug elimination
- Drug pharmacokinetics in renal dysfunction
- Multiple compartment pharmacokinetics
- Nonlinear pharmacokinetics
- Intermittent IV infusions
- Physiological approach to the clearance concept
- Kinetics of the pharmacological effects
- Therapeutic drug monitoring
- Objective
- Introduction
- Introduction
- Drug conc-time profile during repeated intermittent iv infusion
- Multiple administration, s.s. conc, time to s.s., and loading dose
- Factors affecting the plasma conc-time profile Dose, infusion time, total body clearance, and Vd
- Individualization of aminoglycoside dosing regimen
- Determination of aminoglycoside pharmacokinetic parameters
- Recommendation of the appropriate dosing regimen
- Summary
- Plot
- Questions