Total Body Clearance
(CLT)
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- Module
5-Total-body-clearance - Introduction to pharmacokinetics
- IV administration
- Oral administration
- Steady state concept
- Drug elimination
- Drug pharmacokinetics in renal dysfunction
- Multiple compartment pharmacokinetics
- Nonlinear pharmacokinetics
- Intermittent IV infusions
- Physiological approach to the clearance concept
- Kinetics of the pharmacological effects
- Therapeutic drug monitoring
- Objective
- Introduction
- Introduction
- Mathematical expressions for total body clearance
- Physiological approach to total body clearance
- Determination of total body clearance
- Effect of total body clearance and Vd on k and half life
- Drug Clearance
- Summary
- Plot
- Questions