Pharmacokinetic Simulations (Cont'd)

The pharmacokinetic simulations can be used to visualize the effect of changing one or more pharmacokinetic parameters on the drug cone-time profile.

For example:

We can change the dose of the drug and keep all the other parameters constant to examine the effect of changing the dose on the drug conc-time profile.

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
1000 1 7.5 50 .5
Larger doses produce higher
plasma concentration
Dose(mg)
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