Module
1-Introduction to Pharmacokinetic
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objectives
Introduction
Introduction
Drug conc-time profile
Rates and orders of pharmacokinetic processes
Linear and nonlinear pharmacokinetics
Pharmacokinetic modeling
Pharmacokinetic simulations
Summary
Plot
Plot
Linear
Semilog
Help
Questions
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Module
1-Introduction to Pharmacokinetic
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objective
Introduction
Introduction
Drug conc-time profile
Rates and orders of pharmacokinetic processes
Linear and nonlinear pharmacokinetics
Pharmacokinetic modeling
Pharmacokinetic simulations
Summary
Plot
Plot
Linear
Semilog
Help
Questions
Linear pharmacokinetics is characterized by:
1 -
Concentration-dependent half life and volume of distribution
2 -
First-order absorption, distribution and elimination
3 -
Zero-order absorption, distribution or elimination
4 -
The change in dose causes more than proportional increase in conc