The goal of pharmacokinetic data analysis is to estimate the pharmacokinetic parameters that determine the rate of drug absorption, distribution and elimination. Estimation of these parameters requires the assumption of a specific pharmacokinetic model.
Pharmacokinetic models allow quantitative (mathematical) description of the rate of drug absorption, distribution and elimination after administration.
Modeling allows prediction of the drug pharmacokinetic behavior after administration of different dosing regimens by different routes of administration. Also, modeling allows prediction of the changes in drug pharmacokinetic behavior due to physiological and pathological changes.
a- Compartmental modeling
The body is divided into one or more compartments. The model describes the distribution of the drug between the compartments and drug elimination from one or more of the compartments.
b- Physiological modeling
The body is divided into a series of organs or tissue spaces and the model describes the uptake and disposition of the drug in each of these organs.
c- Model-independent approach
This approach does not assume a specific model, but it uses the and to describe the rate of drug disposition.
