Objectives

After completing this module, you should be able to

• Discuss the mechanisms of drug excretion in the urine.

• Determine the drug pharmacokinetic parameters from the urinary excretion rate data.

• Calculate the renal clearance of drugs from the urinary excretion rate data.

• Analyze the effect of changing the dose, total body clearance and the renal clearance on the urinary excretion of drugs.

• Predict the change in the overall elimination rate of drugs due to the change in their renal excretion.