Pharmacokinetic Model

IV bolus

(Dose)

Systemic Circulation

ke

km

Urine

Where k = ke + km

and CLT = CLR + CLM

  • Dose : The administered dose, mg

  • k = (CLT/Vd): The first-order elimination rate constant, hour -1

  • ke = (CLR/Vd) : The first-order renal excretion rate constant, hours -1

  • km = (CLMVd): The first-order excretion rate constant for all other elimination pathways, hours -1