Linear simulation

Module13-Renal Excretion of drugs
Objectives
Introduction
Plot
- Plot
- Linear
- Semilog
- Help
Questions

Module
13-Renal Excretion of drugs

Introduction to pharmacokinetics
IV administration
Oral administration
Steady state concept
- Constant rate infusion
- Multiple Drug Administration
Drug elimination
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
- Two compartment pharmacokinetic model (I)
- Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring

Objective
Introduction

Introduction
Mechanisms of urinary excretion of drugs
Renal excretion rate of drugs
Renal clearance
Fraction of the administered dose excreted in urine
Determination of the Bioavailability from Renal Excretion Data
Factors affecting the renal excretion rate of drugs Dose, k, and k_e
Summary

Plot

Plot
Linear
Semilog
Help

Questions

Renal excretion rate after single iv bolus dose

0

Dose = 0 mg

2000

0

k = 0 hr ^-1

2

0

ke = 0 hr ^-1

0

Sim #

Dose

k

ke

Parameter Definition

Dose : The administered dose, mg

F : The drug bioavailability, no units

Dosing interval : The time between doses, hours

ka : The first order absorption rate constant, hour-1

Vd : The vloume of distribution, liters

k : The first order elimination rate constant, hour-1

Pharmacokinetic Model

F Dose

GIT

ka

Systemic Circulation

(Vd)

k

Dose : The administered dose, mg

F : The drug bioavailability, no units

Dosing interval : The time between doses, hours

ka : The first order absorption rate constant, hour-1

Vd : The vloume of distribution, liters

k : The first order elimination rate constant, hour-1

Directions

Select values for the different PK parameters by dragging the slider for each parameter to the right. The current parameter value will be displayed.

The renal excretion rate-time profile will be graphed when you click plot.

You can change the x and y scale values by clicking the Adjust scale buttons

Adjust X Scale

Enter the maximum value for the X axis. The minimum value for the X axis will be zero.

Adjust Y Scale

Enter the maximum value for the Y axis. The minimum value for the Y axis will be zero.

Help Exit