Relative Bioavailability

When iv drug administration is not possible, the new product is compared with a standard product.

For the new (test) product:

AUCtest =

Ftest Dose

CLT

For the reference standard formulation:

AUCstandard =

Fstandard Dose

CLT

The relative bioavailability of the new product to the standard formulation is:

Frelative =

Ftest

Fstandard
=

AUCtest

AUCstandard
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