Pharmacokinetic Model

F Dose

GIT

ka

Systemic Circulation

(Vd)

k

  • Dose : The administered dose, mg

  • F : The drug bioavailability, no units

  • ka : The first order absorption rate constant, hour-1

  • Vd : The vloume of distribution, liters

  • k = (CLT/Vd) : The first order elimination rate constant, hour-1

Assume that the drug is administered as a single oral dose. All parameters will be kept constant, and only the bioavailability can be changed. Choose different values for bioavailability and simulate the corresponding drug concentration-time profiles.

Simulation