Determination of drug bioavailability

After a single iv drug administration:

AUCiv =

Fiv Dose

CLT

After a single oral drug administration:

AUCoral =

Foral Dose

CLT

When the iv and oral doses are equal and because the bioavailability after iv administration is equal to 1, the absolute bioavailability after oral administration (F) can be calculated as: :

F =

AUCoral

AUCiv
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