Module
8-Bioavailability
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objectives
Introduction
Introduction and definitions
The first-pass effect
Calculation of AUC (trapezoidal rule)
Determination of bioavailability
Significance of the bioavailability and bioequivalence
Pharmacokinetic basis of bioequivalence
Design and evaluation of bioequivalence studies
Summary
Plot
Plot
Linear
Semilog
Help
Questions
×
Module
8-Bioavailability
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Introduction
Introduction
Determination of the pharmacokinetic parameters after a single is drug administration
Factors affecting the drug concentration-time profile
Utilization of the mathematical expressions that describe the plasma conc-time profile after a single , drug administration
Summary
Plot
Plot
Linear
Semilog
Help
Questions
Which of the following preparations requires bioavailability testing ?
1 -
Hydrocortisone cream for local inflammation
2 -
Corticosteroid suspension for intramuscular administration
3 -
Oral radiopaque media
4 -
Aminophylline solution for iv administration