Trapezoidal rule (cont'd)

Area of:

Trapezoid 1 = (

0 + Cp1

2 ) .(t1 - 0)
0,0
1
Cp1, t1
2
Cp2, t2
3
Cp3, t3
4
Cp4, t4
5
Cp5, t5
6
Cp6, t6
tail
Trapezoid 2 = (

Cp1 + Cp2

2 ) .(t2 - t1)
Trapezoid 3 = (

Cp2 + Cp3

2 ) .(t3 - t2)

trapezoid 4, 5 and 6 (as above)

Area of the last trapezoid or area under the tail of the curve

=

last concentration

k =

Cp6

k

AUC = total area of all trapezoids

  • Page 1 of 3
  • 1
  • 2
  • 3