Semilog simulation

Module8-Bioavailability
Objectives
Introduction
Plot
- Plot
- Linear
- Semilog
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Questions

Module
8-Bioavailability

Introduction to pharmacokinetics
IV administration
Oral administration
Steady state concept
- Constant rate infusion
- Multiple Drug Administration
Drug elimination
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
- Two compartment pharmacokinetic model (I)
- Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring

Introduction

Introduction
Determination of the pharmacokinetic parameters after a single is drug administration
Factors affecting the drug concentration-time profile
Utilization of the mathematical expressions that describe the plasma conc-time profile after a single , drug administration
Summary

Plot

Plot
Linear
Semilog
Help

Questions

Oral Bioavailability

Dose = 1000 mg

k_a = 0.9 hr ^-1

CL_T = 6 L/hr

Vd = 30 liters

0

F = 0

1

Sim #

F

Parameter Definition

Dose : The administered dose, mg

F : The drug bioavailability, no units

Dosing interval : The time between doses, hours

ka : The first order absorption rate constant, hour-1

Vd : The vloume of distribution, liters

k : The first order elimination rate constant, hour-1

Pharmacokinetic Model

F Dose

GIT

ka

Systemic Circulation

(Vd)

k

Dose : The administered dose, mg

F : The drug bioavailability, no units

Dosing interval : The time between doses, hours

ka : The first order absorption rate constant, hour-1

Vd : The vloume of distribution, liters

k : The first order elimination rate constant, hour-1

Directions

This is an exercise to simulate how the change in the bioavailability affects the drug concentration-time profile in the body.

You are asked to select values for the bioavailability and then click plot to simulate the plasma concentration-time profile after single oral drug administration, assuming that the dose is 1000 mg, CL_T is 6 L/hr, Vd is 30 L, and the absorption rate constant is 0.9 hr ^-1

Adjust the values for the X and Y axes to see the entire plot by clicking the adjust x scale or adjust y scale buttons.

Adjust X Scale

Enter the maximum value for the X axis. The minimum value for the X axis will be zero.

Adjust Y Scale

Enter the maximum value for the Y axis. The minimum value for the Y axis will be 1/1000 of the maximum value.

Help Exit