is eliminated completely by the kidney. It is filtered in the glomeruli and does not undergo secretion or reabsorption in the renal tubules to any significant extent. So, is a measure of the glomerular filtration rate.
Determination of Creatinine Clearance in Patients
1- Collect all the urine excreted by the patient over a period of 12 to 24 hr.
2- Obtain a plasma sample and determine creatinine plasma concentration.
3- Determine the volume of urine and creatinine concentration in the urine.
4- Calculate the amount of creatinine excreted (amount = volume x conc ).
5- Calculate the renal excretion rate.
6- Calculate the .
The normal value for creatinine clearance in adults is 120 ml/min.
The decrease in kidney function results in a proportional decrease in the .
The decrease in kidney function also decreases the rate of creatinine excretion resulting in an elevated creatinine plasma concentration.
