Factors affecting the
plasma conc-time profile

b- Distribution rate constant, α

Examine the conc-time profiles after administration of the same dose of drugs that have different distribution rate constants. (all other parameters are similar).

Parameters
D(mg) α (hr-1) β (hr-1) Vc (L)
1000 .5 .1 25
α (hr -1)

Larger distribution rate constant leads to faster distribution rate without affecting the elimination rate.

  • Page 3 of 5
  • 1
  • 2
  • 3
  • 4
  • 5