Objectives

After completing this module you should be able to:

• Describe the differences between the one-compartment and the two-compartment pharmacokinetic models.

• Define all the parameters of the two-compartment pharmacokinetic model.

• Utilize the mathematical expressions to calculate the plasma concentration at any time after a single iv drug administration of drugs that follow two-compartment pharmacokinetic model.

• Determine the pharmacokinetic parameters of the two-compartment pharmacokinetic model from plasma concentrations obtained after a single iv administration.

• Analyze the effect of changing one or more of the pharmacokinetic parameters on the plasma concentration-time profile after a single iv administration of drugs that follow two-compartment pharmacokinetic model.