After iv administration, the drug is introduced directly into the central compartment.
Initially no drug in the peripheral compartment
The drug in the peripheral compartment increases and then decreases
All the drug is in the central compartment
The drug in the central compartment decreases due to distribution and elimination
No drug is excreted
The drug excreted increases until the entire dose is eliminated
Initially, the drug in the central compartment decreases rapidly because of simultaneous distribution and elimination. During the elimination phase the drug in the central compartment declines at a rate dependent on the drug elimination rate.
The drug in the peripheral compartment increases initially because of drug distribution then declines parallel to the drug decline in the central compartment.
The amount of the drug excreted will increase until all the administered dose is eliminated.
