Pharmacokinetic Model

Peripheral
compartment

k21

k12

IV bolus

Dose

Central
compartment

k10

Cp = A e-α t + B e-β t

  • A and B : The hybrid coefficients for the distribution and elimination phases, both have units of concentrations, amount/volume.

  • α : The first order hybrid rate constant for the distribution process, hour -1

  • β : The first order hybrid rate constant for the elimination process, hour -1

Simulation