Semilog simulation

Module17- Multiple Compartment Models (I)
Objectives
Introduction
Plot
- Plot
- Linear
- Semilog
- Help
Questions

Module
17- Multiple Compartment Models (I)

Introduction to pharmacokinetics
IV administration
Oral administration
Steady state concept
- Constant rate infusion
- Multiple Drug Administration
Drug elimination
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
- Two compartment pharmacokinetic model (I)
- Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring

Objective
Introduction

Introduction
One-compartment model versus two-compartment model
The two-compartment pharmacokinetic model
Plasma concentration-time profile in the two-compartment model
Determination of the pharmacokinetic parameters
Factors affecting the plasma concentration-time profile
Summary

Plot

Plot
Linear
Semilog
Help

Questions

Two compartment model - A single iv bolus dose

0

A = 0 mg/L

1000

0

B = 0 mg/L

100

0

α = 0 hr-1

3

0

β = 0 hr-1

3

Sim #

A

B

α

β

Directions

Select values for the different PK parameters by dragging the slider for each parameter on the right. The current parameter value will be displayed.

The drug concentration-time profile will be graphed when you click plot.

You can change the x and y scale values by clicking the adjust scale buttons.

Adjust X Scale

Enter the maximum value for the X axis. The minimum value for the X axis will be zero.

Adjust Y Scale

Enter the maximum value for the Y axis. The minimum value for the Y axis will be 1/100 of the maximum value.

Help Exit