Higher doses produce higher initial drug concentrations, but the rate of decline of the drug concentration does not change.
Example:
Theophylline is a drug used in the treatment of some respiratory diseases. The minimum effective conc of theophylline is 10 mg/L and the minimum toxic cone is 20 mg/L. What are the minimum and the maximum doses of theophyllMe that will achieve concentrations between 10 and 20 mg/L if theophylline Vd is 30 L.
