Determination of the Pharmacokinetic Parameters
after a Single IV Dose

The plasma concentrations obtained after iv drug administration are plotted on the semilog scale and the best line that goes through the concentrations is drawn.

The Volume distribution can be determined from the dose of the drug and the initial plasma concentration.

Vd =

Dose

Cp0

The elimination rate constant (k) can be determined from the slope of the line:

slope =

-k

2.303
Cp0
Slope = -k/2.303
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