A general anesthetic has a volume of distribution of 2 L/kg, a half life of 3 hours and a minimum effective concentration of 1 mg/L (i.e. The drug is effective as long as the plasma concentration is above 1 mg/L). What will be the expected duration of effect after iv administration of 16 mg/kg of this anesthetic ? (i.e. How long it will take for the initial plasma concentration after iv administration of 16 mg/kg of this drug to decrease to 1 mg/L ?)