A general anesthetic has a volume of distribution of 2 L/kg, a half life of 2 hours and a minimum effective concentration of 1 mg/L (i.e. The drug is effective as long as the plasma concentration is above 1 mg/L). What will be the iv dose of this anesthetic that should produce an effect for 8 hours ? (i.e. What is the dose required to achieve an initial plasma concentration that will decline to 1 mg/L after 8 hours or 4 half lives ?).