Questions

Procainamide is an antiarrhythmic drug that have a therapeutic range of 4-10 mg/L. What is the iv procainamide loading dose that should be given to achieve plasma concentration of 8 mg/L immediately after administration if procainamide volume of distribution is 2 L/kg ?

1 - 4 mg/kg 2 - 16 mg 3 - 16 mg/kg 4 - 8 mg/kg