After iv administration of a drug, the initial plasma concentration is dependent on the administered dose and the
Higher doses produce higher initial drug concentrations when Vd is constant. Also, smaller will result in higher initial drug concentration when the dose is constant.
The rate of decline of the plasma drug concentration is dependent on the The is dependent on the CLT and Vd, and is determined from: (CLT/Vd = k).
Larger k, means shorter half-life and faster rate of drug elimination from the body.
