IV Drug Administration

After iv drug administration, the initial drug concentration depends on the dose and Vd of the drug.

Cp0=

Dose

Vd

When drug elimination follows first-order kinetics, the amount of the drug in the body and the plasma drug concentration decline at a rate dependent on the elimination rate constant(k).

Cp = Cp0 e-kt

The elimination rate constant(k). is dependent on Vd and CLT (k = CLT/Vd).

Cp0
Slope = -k/2.303
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