Determination of the Pharmacokinetic Parameters (cont'd)

The half life, can be estimated from k

t1/2 =

0.693

k

or graphically by calculating the time required for the plasma concentration to decrease by 50%.


The total body clearance, (CLT) can be calculated from k and Vd .

CLT = k Vd

The area under the curve can be calculated:

AUC =

Cp0

k
  =  

Dose

k Vd
Cp0
Slope = -k/2.303
t = ?
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