It is clear that the pharmacokinetic characteristics of drugs are different in different patient populations. Within each population there is also inter-individual variability in drug pharmacokinetics. The difference in drug pharmacokinetics in different patients is one of the main causes of variability in the response of patients to drug therapy.
Individualization of the dosing regimen for each patient is necessary to ensure optimal drug response.
Which drugs ?
- Drugs with narrow
- Drugs with large variability in their pharmacokinetic parameters
- Drugs administered to patients at high risk of toxicity
The following discussion will deal with dosage adjustment in patients with renal dysfunction.
This will be an example of dosage adjustment in a specific patient population. Similar approaches can be adopted for dosage adjustment in different patient populations.
