Objectives

After completing this module, you should be able to

• Identify some causes of variability in drug pharmacokinetics in different individuals.

• Determine the factors that affect the change in drug pharmacokinetics in patients with renal dysfunction during multiple drug administration.

• Analyze the effect of changing the kidney function and the fraction of dose excreted unchanged in urine on drug pharmacokinetics.

• Recommend an appropriate dosing regimen in patients with renal dysfunction.

• Evaluate the appropriateness of dosing regimens in patients with renal dysfunction.