Pharmacokinetic Model

F Dose

GIT

ka

F Dose

Systemic Circulation
(Vd)

ke

Renal excretion

k - ke

Other excretion
pathways

ke = Rate constant for the renal excretion process = f k

k - ke = The rate constant for all other pathways = ( 1 - f) k

Where f is the fraction of dose excreted unchanged in urine.

  • F Dose : The bioavailable dose, mg

  • k a : The first-order absorption rate constant, hour -1

  • Vd:  The volume of distribution, liters

  • k = (CLT/Vd): The overall first-order elimination rate constant, hour -1

  • ke = (CLR/Vd):  The first-order renal excretion rate constant, hour -1

Simulation