Questions

Penicillin G is an antibiotic that is eliminated mainly unchanged in urine by the kidney. Geriatric patients usually eliminate penicillin G at a much slower rate compared to younger patients. The most probable cause of this slower rate of penicillin G elimination in geriatric patients is:

1 - Reduced kidney function 2 - Reduced liver function 3 - Smaller body weight 4 - Decreased plasma protein binding