Administration of multiple drugs can result in drug-drug interactions that can alter the absorption, distribution or elimination of one or more of the administered drugs.
Cimetidine can significantly inhibit theophylline metabolism leading to reduction of theophylline .
This interaction can lead to significantly higher and toxic theophylline plasma concentrations.
Probenecid inhibits the renal elimination of ampicillin by inhibiting its secretion. This leads to prolonged ampicillin and lower ampicillin .
This interaction is used therapeutically to achieve higher ampicillin conc.
