Establishment of a therapeutic drug monitoring service

Requirements:

- Sensitive, accurate, specific and rapid method of drug analysis in biological fluids

- Basic and clinical pharmacokinetic knowledge

Procedures :

1- Obtain information about the patient (demographic and past medical history).

2- Use the available patient information to design an appropriate initial dosing regimen for the patient.

3- If the patient already receiving the drug to be monitored, obtain the dosing history.

4- Plan an appropriate drug monitoring strategy including plasma sampling schedule that allow the determination of the patient specific pharmacokinetic parameters for the drug.

5- Calculate the patient specific drug pharmacokinetic parameters.

6- Use the patient specific pharmacokinetic parameters to adjust the drug dosing regimen, if necessary, to achieve the desired therapeutic drug concentration.

7- Develop drug therapy management plan that include periodic monitoring of the plasma drug concentration.