Module
23- Therapeutic drug monitoring
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objectives
Introduction
Introduction
The therapeutic range of drugs
Causes of pharmacokinetic variability Body weight, age, drug-drug interaction, genetic factors, pregnancy, and diseases
Benefits of therapeutic drug monitoring
Drug candidates for therapeutic drug monitoring
Establishment of a therapeutic drug monitoring service
Summary
Plot
Plot
Linear
Semilog
Help
Questions
×
Module
13- Therapeutic drug monitoring
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objective
Introduction
Introduction
The therapeutic range of drugs
Causes of pharmacokinetic variability Body weight, age, drug-drug interaction, genetic factors, pregnancy, and diseases
Benefits of therapeutic drug monitoring
Drug candidates for therapeutic drug monitoring
Establishment of a therapeutic drug monitoring service
Summary
Plot
Plot
Linear
Semilog
Help
Questions
The characters that make a drug good candidate for therapeutic drug monitoring include:
1 -
Drugs with narrow therapeutic range
2 -
Drugs with large variability in their pharmacokinetics
3 -
Drugs administered to high risk patients
4 -
All of the above