Pharmacokinetic Model

F Dose

 
GIT

ka

Systemic
circulation

(Vd)

k

  • Dose :  The administered dose, mg

  • F :  The drug bioavailability, no units

  • Dosing interval :  The time between doses, hours

  • ka :  The first order absorption rate constant, hour -1

  • Vd :  The volume of distribution, liters

  • k = (CLT/Vd) :  The first order elimination rate constant, hour -1

Simulation