Therapeutic drug monitoring

Therapeutic drug monitoring is the use of blood/plasma drug concentration measurement as a tool for individualization of drug therapy.

This concept depends on the fact that many drugs exert their desired therapeutic effects with minimum adverse effects when their blood/plasma concentrations are kept within a certain range known as the therapeutic range.

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Therapeutic range
Minimum toxic concentration
Minimum effective concentration

This concept has been developed because :

- Development in the area of pharmacokinetics.

- Establishment of the conc-effect and conc-toxicity relationships for many drugs.

- Availability of instruments for rapid determination of drug blood concentration.

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