Methods for the determination of plasma drug concentration

- High pressure liquid chromatography

- Liquid chromatography/Mass spectroscopy

- Gas chromatography

- Radioimmunoassay

These methods are sensitive, specific, precise and require complex sample preparation procedures. The turn-over time is usually long.

These methods are usually used in research, but not in routine clinical sample analysis.

- Enzyme immunoassays

- Fluorescence polarization immunoassay

These methods are sensitive, specific, rapid and require simple sample preparation procedures. These methods are usually used in clinical settings for routine sample analysis.

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