Pharmacokinetic Model

Iv bolus

(Dose 100 mg)

Systemic Circulation

(Vd)

k

t1/2 =

0.693

k
  • Dose : The administered dose, 100 mg

  • k : The first order elimination rate constant, hour-1

  • half life : The time required for the amount of the drug in the body to decrease by 50%, hours

Assume that a single dose of 100 mg is administered by iv bolus injection. Choose different values for the half life and simulate the drug amount-time profiles.