Half life

The half life is defined as the time required for the amount or the concentration of the drug in the body to decrease by one-half (50%).

When drug elimination follows first-order kinetics, the half life of the drug is constant and is related to the elimination rate constant.

t1/2

t1/2

First order elimination

For first order elimination, the time required for the amount of drug in the body to decrease from 100 mg to 50 mg is the same as the time required for the drug amount to decrease from 50 mg to 25 mg.

  • Page 1 of 2
  • 1
  • 2