Graphical determination of the half life

a- An iv dose of the drug is administered, then plasma samples are obtained. Plot the plasma drug conc versus time on a semilog graph paper.

b- Draw the best line that goes through the sample concentrations.

c- Starting at any point on the line, find out the time required for the y-coordinate of this point to decrease by 50%.

d- This is the half life.

t1/2

t1/2

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