Aminoglycosides are antimicrobial agents that have bactericidal activity against Gram-negative aerobic bacteria.
Individualization of aminoglycoside dosing regimen is important to ensure optimal efficacy with minimal toxicity. The goal of conventional aminoglycoside dosing adjustment strategies is to maintain plasma conc within a certain range.
Guidelines for plasma aminoglycoside conc for most infections:
|
Gentamicin, tobramycin and netilmicin |
Amikacin |
| Maximum conc |
6 - 10 mg/L |
20 - 30 mg/L |
| Minimum conc |
0.5 - 2 mg/L |
1 - 8 mg/L |
has been utilized effectively in the treatment of infections. The above guidelines do not apply to the . The following discussion will cover the traditional aminoglycoside dosing adjustment method.
