Objectives

After Completing this module you should be able to:

• Describe the plasma conc-time profile during multiple intermittent iv infusion.

• Analyze the effect of changing one or more of the pharmacokinetic parameters on the maximum and minimum steady state drug concentration

• Determine the steady state maximum and minimum drug conc during repeated intermittent iv infusions.

• Predict aminoglycoside half life based on the patient's kidney function.

• Determine the patient's specific aminoglycoside pharmacokinetic parameters.

• Recommend the appropriate aminoglycoside dosing regimen based on the patient's specific pharmacokinetic parameters.