Drug Administration by Intermittent IV Infusion

This means drug administration by constant rate iv infusion for a short period of time. The short iv infusion is repeated every dosing interval (τ). After repeated administration of the short iv infusions, steady state is achieved.

Following repeated iv infusions :

 
IV infusion

Plasma drug concentration

drug
elimination

The drug accumulates in the body until steady state is achieved.

The maximum and the minimum plasma concentrations will be constant at steady state if the dose, dosing interval and infusion duration are kept constant.

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