Questions

A patient was taking 90 mg of gentamicin every 12 hours to treat a Gram negative infection. The patient developed acute kidney failure, and his physician was worried because the kidney is the major organ responsible for gentamicin elimination. What will happen if the patient continue taking his 90 mg every 12 hours gentamicin ?

1 - Gentamicin total body clearance will be higher and s.s. conc will be lower 2 - Gentamicin total body clearance will be lower and s.s. conc will be lower 3 - Gentamicin total body clearance will be lower and s.s. conc will be higher 4 - Gentamicin total body clearance will be higher and s.s. conc will be higher