Questions

A 65 yr, 60 kg patient was admitted to the hospital because of acute episode of pneumonia. The initial microbiological examination indicated that the causative organism is very sensitive to tobramycin and the serum creatinine was 1.6 mg/dl. What will be the best initial estimate for tobramycin pharmacokinetic parameters that can be used to determine the initial tobramycin dose in this patient ?

1 - Any value for the parameters can be used initially 2 - The average text book estimate for tobramycin parameters 3 - The average estimates in a similar patient population 4 - Cannot give tobramycin without knowing the patient’s specific parameters.