Pharmacokinetic Model

IV infusion

(short duration)

Systemic
Circulation

k

(Vd)
  • Dose :  The dose administered as constant rate infusion of short duration, mg

  • Infusion time (t') :  The duration of the infusion, hours

  • Dosing interval :  The time between doses. hours

  • Vd :  The volume of distribution, liters

  • k = (CLT/Vd) :  The first order elimination rate constant. hour -1