Steady state drug/metabolite conc
during repeated drug administration

Cpaverage ss=

F D

k Vd τ

The drug accumulates in the body during repeated administration until steady state is achieved.

The steady state drug concentration depends on the drug administration rate and the drug clearance, CLT.

Also the metabolite will accumulate until steady state is achieved.

The steady state metabolite conc depends on the metabolite formation rate and the metabolite clearance,CLT(m).

The steady state metabolite conc can be higher or lower than the drug conc depending on the drug and the metabolite pharmacokinetic parameters.

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