Factors affecting the drug/metabolite
profiles after iv drug administration.

a- Dose

Examine the drug and metabolite conc-time profiles after administration of different iv doses of the same drug. Assuming that all other pharmacokinetic parameters for the drug and metabolite do not change.

Parameters
D (mg) Vd (L) CLΤ(L/hr) fm CLΤ(m)(L/hr) Vd(m) (L)
1000 25 1.75 .8 1 10
Dose (mg)

Detailed conclusion

Administration of higher dose of the drug results in the formation of larger amount of the metabolite since fm is constant.