- Increasing the drug dose results in proportional increase in the drug AUC.
- Increasing the drug dose leads to proportional increase in the amount of metabolite formed in vivo. This is because the fraction of the drug converted to the metabolite (fm) does not change.
- The increase in metabolite formation will cause proportional increase in the metabolite AUC.
- The metabolite/drug AUC ratio after administration of increasing doses of the drug remains constant.