Factors affecting the steady state drug/metabolite
conc ratio during multiple iv drug administration.

a - Dose

Examine the drug and metabolite conc-time profiles during multiple administration of different doses of the same drug. All parameters are dose independent.

Parameters
D (mg) Vd (L) CLΤ(L/hr) fm CLΤ(m)(L/hr) Vd(m) (L)
1000 15 1 .8 1.2 12

1000 mg q 8 hr

Dose

Detailed conclusion

Administration of higher doses of the drug cause proportional increase in the steady state drug and metabolite conc. The steady state drug/metabolite conc ratio stays constant.