- Increasing the drug dose results in proportional increase in the average steady state drug concentration.
- Increasing the drug dose leads to a proportional increase in the metabolite formation rate. This is because the fraction of the drug converted to the metabolite (fm) does not change.
- The increase in metabolite formation will cause proportional increase in the metabolite steady state concentration.
- The metabolite/drug steady state conc ratio after administration of increasing doses of the drug will stay constant.