Objectives

After completing this module, you should be able to:

• Appreciate the importance of studying metabolite kinetics after a single and repeated drug administration.

• Analyze the effect of changing each of the drug and metabolite pharmacokinetic parameters on the drug and metabolite profiles after a single drug administration.

• Identify the factors that affect the steady state drug to metabolite concentration ratio during multiple drug administration.

• Analyze the effect of changing each of the drug and metabolite pharmacokinetic parameters on the drug and metabolite profiles at steady-state during multiple drug administration.