Drug/metabolite profiles after iv drug administration (cont'd)

Factors affecting the steady state
drug/metabolite conc ratio (Cont'd)

e- Metabolite total body clearance

Examine the drug and metabolite conc-time profiles during multiple administration of different drugs that form metabolites with different CL_T(m). (All other parameters are similar)

Parameters
D (mg)	Vd (L)	CLΤ(L/hr)	f_m	CLΤ(m)(L/hr)	Vd(m) (L)
300	50	10	.8	6	20

CL_T(m) (L/hr)

Detailed conclusion

Lower CL_T(m) causes proportional increase in the metabolite steady state conc without affecting the drug steady state conc, i.e. higher metabolite/drug conc ratio.

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Factors affecting the steady state drug/metabolite conc ratio (Cont'd)

Parameters:

Metabolite total body clearance:

The metabolite total body clearance (CLT(m))

Factors affecting the steady state
drug/metabolite conc ratio (Cont'd)

The metabolite total body clearance (CL_T(m))