Dose : The administered dose, mg
F : The drug bioavailability, no units
Dosing interval : The time between doses, hours
ka : The first order absorption rate constant, hour-1
Vd : The vloume of distribution, liters
k : The first order elimination rate constant, hour-1
F Dose
GIT
ka
Systemic Circulation
(Vd)
k
Dose : The administered dose, mg
F : The drug bioavailability, no units
Dosing interval : The time between doses, hours
ka : The first order absorption rate constant, hour-1
Vd : The vloume of distribution, liters
k : The first order elimination rate constant, hour-1
Select values for the different PK parameters by dragging the slider for each parameter on the right. The current parameter value will be displayed.
The drug and metabolite concentration-time profiles will be graphed when you click plot.
You can change the x and y scale values by clicking the Adjust scale buttons
Enter the maximum value for the X axis. The minimum value for the X axis will be zero.
Enter the maximum value for the Y axis. The minimum value for the Y axis will be zero.